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Ultrastructural visualization of protein-4 binding insulin-like growth factors in cow ovarian follicles

  • Experimental Biology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Protein-4 that binds the insulin-like growth factors (IGFBP-4) was visualized in the basal membrane of some vessels and follicles and in extracellular membrane surrounding thecal cells in middle-sized cow ovarian follicles. Examinations of serial sections of thecal granular cells showed highly specialized sites for detection of this protein on plasma membranes and highly specialized endosomes responsible for accumulation of IGFBP-4 in granular cells. These data point to an active role palyed by the extracellular ovarian matrix in the binding and accumulation of insulin-like growth factor and to high specificity of internalization and exocytosis of IGFBP-4 by ovarian granular cells.

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References

  1. J. F. Cara,Horm. Res.,42, 49–54 (1994).

    Article  PubMed  CAS  Google Scholar 

  2. W. S. Cohrick, A. Gockerman, and D. R. Clemmons,J. Biol. Chem.,264, 7795–7800 (1989).

    Google Scholar 

  3. L. C. Giudice,Am. J. Med.,98, Suppl. IA, 48–55 (1995).

    Article  Google Scholar 

  4. W. B. Grant, T. J. Wargovich, E. A. Ellis,et al., Circulation,89, 1511–1517 (1994).

    PubMed  CAS  Google Scholar 

  5. R. W. Grimes, J. A. Barber, S. Shimasaki, and J. M. Hammond,Biol. Reprod,50, 695–701 (1994).

    Article  PubMed  CAS  Google Scholar 

  6. J. I. Jones, A. Gockerman, W. H. Busby,et al., Proc. Natl. Acad. Sci. USA,90, 10553–10557 (1993).

    Article  PubMed  CAS  Google Scholar 

  7. M. M. Rechler and A. L. Brown,Growth Regul.,2, 55–68 (1992).

    PubMed  CAS  Google Scholar 

  8. I. J. Spicer and S. E. Echternkamp,Domest. Anim. Endocrinol.,12, 223–245 (1995).

    Article  PubMed  CAS  Google Scholar 

  9. H. Vlassara, M. Brownlee, K. R. Manogue,et al., Science,240, 1546–1548 (1988).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Pediatrics and Human Reproduction, East Siberian Research Center, Siberian Division of Russian Academy of Medical Sciences, Irkutsk

    A. L. Glazyrin & S. I. Kolesnikov

  2. Department of Development and Reproduction, Roslin Institute, Midlotian, Scotland

    D. G. Armstrong, K. G. Guttieras, T. A. Bramley & R. Webb

Authors
  1. A. L. Glazyrin
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  2. D. G. Armstrong
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  3. K. G. Guttieras
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  4. T. A. Bramley
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  5. R. Webb
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  6. S. I. Kolesnikov
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 12, pp. 676–680, December, 1998

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Glazyrin, A.L., Armstrong, D.G., Guttieras, K.G. et al. Ultrastructural visualization of protein-4 binding insulin-like growth factors in cow ovarian follicles. Bull Exp Biol Med 126, 1244–1247 (1998). https://doi.org/10.1007/BF02447164

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  • DOI: https://doi.org/10.1007/BF02447164

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