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Effect of thyrotropin on the activity of calpains in the thyroid gland. The role of second messengers

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Specific features of calpain regulation were studied in rat thyrocytes. Stimulation with physiological concentrations of thyrotropin induced a considerable activation of studied proteinases. Activation developed over a few minutes and lasted for more than 30 min. Studies of the effects of a BAPTA chelator, ionomycin, dibutyryl cAMP, and phorbol ester showed that the process described did not depend on the main systems of second messengers in the thyroid gland.

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Authors and Affiliations

  1. Department of Biochemistry, I. P. Pavlov Ryazan' State Medical University, Moscow, USSR

    E. A. Stroev, N. N. Bulaeva & M. Yu. Kochukov

Authors
  1. E. A. Stroev
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  2. N. N. Bulaeva
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  3. M. Yu. Kochukov
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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No 12, pp. 649–651, December, 1998

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Stroev, E.A., Bulaeva, N.N. & Kochukov, M.Y. Effect of thyrotropin on the activity of calpains in the thyroid gland. The role of second messengers. Bull Exp Biol Med 126, 1218–1220 (1998). https://doi.org/10.1007/BF02447156

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  • DOI: https://doi.org/10.1007/BF02447156

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