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Effect of bombesin (6–14) on arterial pressure in health and in hypovolemic shock

  • Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Injection of active fragment of the neuropeptide bombesin (6–14) into cerebral ventricles of intact rabbits induces marked arterial hypertension accompanied by bradycardia and partial redistribution of blood to specialized heat-emitting organs (auricular conchae), which reduces body temperature. After a considerable blood loss, the peptide normalizes arterial pressure without affecting cardiac activity and body temperature. It is suggested that bombesins may be used for compensation of arterial hypotension during the early period of hypovolemic shock.

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Authors and Affiliations

  1. Department of Normal Physiology, Laboratory of Physiology, of Extremal States, Academy of Military Medicine, St. Petersburg, USSR

    A. T. Mar'yanovich, V. N. Tsygan, Yu. I. Shipilov, M. A. Signaevskii & S. I. Churkina

  2. Department for the Chemistry of Naturally Occurring Compounds, St. Petersburg State University, St. Petersburg, USSR

    A. T. Mar'yanovich, V. N. Tsygan, Yu. I. Shipilov, M. A. Signaevskii & S. I. Churkina

Authors
  1. A. T. Mar'yanovich
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  2. V. N. Tsygan
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  3. Yu. I. Shipilov
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  4. M. A. Signaevskii
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  5. S. I. Churkina
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 10, pp. 372–374, October, 1996

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Mar'yanovich, A.T., Tsygan, V.N., Shipilov, Y.I. et al. Effect of bombesin (6–14) on arterial pressure in health and in hypovolemic shock. Bull Exp Biol Med 122, 974–975 (1996). https://doi.org/10.1007/BF02447010

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  • DOI: https://doi.org/10.1007/BF02447010

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