Participation of cholesterol in hypochlorite-induced oxidation of cholesterol-phosphatidylcholine liposomes
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The effect of cholesterol on hypochlorite-induced lipid peroxidation is studied in cholesterol-phosphatidylcholine liposomes. Cholesterol is shown to promote the accumulation of lipid peroxidation products in the presence of 0.1–3 mM hypochlorite anion in the incubation medium. The content of 2-thiobarbituric acid-reactive products is maximal at a cholesterol: phosphatidylcholine molar ratio of 1∶1. On the other hand, in the presence of low hypochlorite concentrations (10–100 μM) cholesterol is found to inhibit lipid peroxidation.
Key Wordshypochlorite lipid peroxidation cholesterol phosphatidylcholine liposomes
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