Participation of cholesterol in hypochlorite-induced oxidation of cholesterol-phosphatidylcholine liposomes
The effect of cholesterol on hypochlorite-induced lipid peroxidation is studied in cholesterol-phosphatidylcholine liposomes. Cholesterol is shown to promote the accumulation of lipid peroxidation products in the presence of 0.1–3 mM hypochlorite anion in the incubation medium. The content of 2-thiobarbituric acid-reactive products is maximal at a cholesterol: phosphatidylcholine molar ratio of 1∶1. On the other hand, in the presence of low hypochlorite concentrations (10–100 μM) cholesterol is found to inhibit lipid peroxidation.
Key Wordshypochlorite lipid peroxidation cholesterol phosphatidylcholine liposomes
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- 1.Yu. A. Vladimirov and A. I. Archakov,Lipid Peroxidation in Biological Membranes [in Russian], Moscow (1972), pp. 1–252.Google Scholar
- 2.S. A. Evgina, O. M. Panasenko, V. I. Sergienko, and Yu. A. Vladimirov,Biol. Membr.,9, 946–953 (1992).Google Scholar
- 3.V. G. Ivkov and G. N. Berestovskii, in:Dynamic Structure of the Lipid Bilayer [in Russian], Moscow (1981), pp. 40–244.Google Scholar
- 4.O. M. Panasenko and V. I. Sergienko,Biol. Member.,10, 341–382 (1993).Google Scholar
- 6.Biological Membranes. A Practical Approach, Eds. J. B. C. Findlay and W. H. Evans, IRL Press, Ltd. Oxford-Washington, DC (1987).Google Scholar
- 8.S. W. Edwards,Biochemistry and Physiology of Neutrophils, Cambridge (1994).Google Scholar