Abstract
The effect of cholesterol on hypochlorite-induced lipid peroxidation is studied in cholesterol-phosphatidylcholine liposomes. Cholesterol is shown to promote the accumulation of lipid peroxidation products in the presence of 0.1–3 mM hypochlorite anion in the incubation medium. The content of 2-thiobarbituric acid-reactive products is maximal at a cholesterol: phosphatidylcholine molar ratio of 1∶1. On the other hand, in the presence of low hypochlorite concentrations (10–100 μM) cholesterol is found to inhibit lipid peroxidation.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 5, pp. 516–519, May, 1996
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Momynaliev, K.T., Govorum, V.M., Panasenko, O.M. et al. Participation of cholesterol in hypochlorite-induced oxidation of cholesterol-phosphatidylcholine liposomes. Bull Exp Biol Med 121, 468–470 (1996). https://doi.org/10.1007/BF02446938
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DOI: https://doi.org/10.1007/BF02446938