Skip to main content
SpringerLink
Log in

Immune response, phagocytosis, and detoxication ability under the unfluence of peptide and amino acid preparations

  • Biophysics and Biochemistry
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Dipeptides Glu-Trp and Lys-Asp and peptide mixtures of the 5th thymosine fraction, as well as thymaline, stimulate the immune response when applied subcutaneously during 5 days and intensify the activity of neutrophils and protect splenocytes from the toxic effect of benzene and aflatoxin B1 in vitro. Amino acids (Glu, Trp, Lys, Asp, and Arg) and amino acid mixtures (levamine-70, cerebrolysine, and aviamine) differently affect the indexes of specific and nonspecific resistance under the same conditions and at the same dose.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. G. A. Belokrylov, in:Immunophysiology, E. A. Korneva (Ed.) [in Russian], St. Petersburg (1993), pp. 320–367.

  2. S. M. Gusman, in:Chronic Occupational Benzene Poisoning [in Russian], Baku (1970), pp. 120–121.

  3. V. N. Zakharov, A. V. Karaulov, V. V. Sokolov, and V. N. Frash, in:Changes in the Blood System Exposed to Radiation and Benzene [in Russian], Novosibirsk (1990), pp. 199–205.

  4. P. N. Kiselev, in:Toxicology of Infectious Processes [in Russian], Leningrad (1971), pp. 284–289.

  5. I. V. Molchanova, “Immunomodulatory properties of gastrointestinal peptides,” Abstract of Dissertation [in Russian], Leningrad (1990).

  6. V. G. Morozov, V. Kh. Khavinson, and O. A. Pisarev,Dokl. Akad. Nauk SSSR,233, No. 3, 491–494 (1977).

    CAS  Google Scholar 

  7. V. A. Tutel'yan and L. V. Kravchenko,Mycotoxins (Medical and Biological Aspects) [in Russian], Moscow (1985).

  8. G. A. Belokrylov, I. V. Molchanova, and E. I. Sorochinskaya,Int. J. Immunopharmacol. 12, No. 8., 841–845 (1990).

    Article  PubMed  CAS  Google Scholar 

  9. G. A. Belokrylov, O. Ya. Popova, I. V. Molchanova,et al., ——Ibid.,14, No. 7, 1285–1292 (1992).

    Article  PubMed  CAS  Google Scholar 

  10. A. L. Goldstein, A. Guha, M. M. Zatz,et al., Proc. Natl. Acad. Sci. USA,69, No. 7, 1800–1803 (1972).

    Article  PubMed  CAS  Google Scholar 

  11. N. K. Jerne and A. A. Nordin,Science,140, 405–406 (1963).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg

    G. A. Belokrylov, O. N. Derevnina, O. Ya. Popova, I. V. Molchanova & E. I. Sorochinskaya

Authors
  1. G. A. Belokrylov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. N. Derevnina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. O. Ya. Popova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I. V. Molchanova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. I. Sorochinskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 5, pp. 509–512, May, 1996

Rights and permissions

Reprints and permissions

About this article

Cite this article

Belokrylov, G.A., Derevnina, O.N., Popova, O.Y. et al. Immune response, phagocytosis, and detoxication ability under the unfluence of peptide and amino acid preparations. Bull Exp Biol Med 121, 462–464 (1996). https://doi.org/10.1007/BF02446936

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02446936

Key Words

Search

Navigation