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Role of nitric oxide in the mechanisms of Verograffin nephrotoxicity

  • Biophysics and Biochemistry
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Nephrotoxicity of radiopaque agents and the role of nitric oxide in its realization are studied in Wistar rats with Verograffin-induced acute renal insufficiency. Experiments demonstrate a significant decrease in nitric oxide production in the kidneys due to inhibition of constitutive NO-synthetase and disturbances of renal function, hemodynamics, and electrolyte balance. These changes are prevented by simultaneous injection of verapamil.

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Authors and Affiliations

  1. Department of Nephrology, Faculty of Postgraduate Education, I. M. Sechenov Moscow Medical Academy, Moscow

    F. U. Dzgoeva, I. M. Kutyrina, A. A. Ivanov, E. N. Burgova & A. F. Vanin

  2. Laboratory of Biopolymer Physical Chemistry, N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow

    F. U. Dzgoeva, I. M. Kutyrina, A. A. Ivanov, E. N. Burgova & A. F. Vanin

Authors
  1. F. U. Dzgoeva
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  2. I. M. Kutyrina
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  3. A. A. Ivanov
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  4. E. N. Burgova
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  5. A. F. Vanin
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 10, pp. 396–399, October, 1997

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Dzgoeva, F.U., Kutyrina, I.M., Ivanov, A.A. et al. Role of nitric oxide in the mechanisms of Verograffin nephrotoxicity. Bull Exp Biol Med 124, 968–970 (1997). https://doi.org/10.1007/BF02446835

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  • DOI: https://doi.org/10.1007/BF02446835

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