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Comparative study of the effects of recombinant tumor necrosis factor and synthetic peptides corresponding to its fragments on phagocytosis mediated by Fc- and MF-receptors

  • Genetics
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effects of human recombinant tumor necrosis factor and its peptides on the macrophage-like cells of continuous cell line P388D1 were studied. One of the peptides, 123–131, was found capable of not only mimicking, but also of blocking the effects of recombinant tumor necrosis factor. The results permit us to tentatively identify the 123–131 site of the factor molecule as being responsible for its activating effect on macrophages.

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Authors and Affiliations

  1. Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg

    I. G. Konyaev, I. S. Freidlin, V. A. Maiorov & V. P. Zav'yalov

  2. Institute of Immunology, Lyubuchany, Moscow Region

    I. G. Konyaev, I. S. Freidlin, V. A. Maiorov & V. P. Zav'yalov

Authors
  1. I. G. Konyaev
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  2. I. S. Freidlin
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  3. V. A. Maiorov
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  4. V. P. Zav'yalov
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No 3, pp. 304–308, March, 1996

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Konyaev, I.G., Freidlin, I.S., Maiorov, V.A. et al. Comparative study of the effects of recombinant tumor necrosis factor and synthetic peptides corresponding to its fragments on phagocytosis mediated by Fc- and MF-receptors. Bull Exp Biol Med 121, 280–283 (1996). https://doi.org/10.1007/BF02446770

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  • DOI: https://doi.org/10.1007/BF02446770

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