Abstract
It is demonstrated that immobilization stress against the background of lowered catalase activity impairs the function of the sarcoplasmic reticulum Ca pump, particularly at high Ca2+ levels. the membranes of intracellular Ca2+ depots are destroyed much more rapidly than in the control, which results in Ca2+ release. Administration of delta sleep-inducing peptide to control animals results in a 30% increase in catalase activity for an unchanged level of superoxide dismusase and markedly improves the function of the Ca-transporting system at elevated levels of free Ca2+. A long-term stress after administration of the peptide not only causes no damage to the Ca-transporting system but actually increases its efficiency (compared with the control) at a high catalase level.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No 3, pp. 248–251, March, 1996
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Sazontova, T.G., Golantsova, N.E., Kolmykova, S.N. et al. The effect of delta-sleep-inducing peptide on the Ca-transporting system of the sarcoplasmic reticulum and activity of the myocardial antioxidant enzymes. Bull Exp Biol Med 121, 229–232 (1996). https://doi.org/10.1007/BF02446753
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DOI: https://doi.org/10.1007/BF02446753