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Halogen analogs of thymidine increase the level of chromosome aberrations in cells of patients with Fanconi's anemia

  • Genetics
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Lymphocytes of two patients with Fanconi's anemia were cultured with halogen analogs of thymidine. These substances reliably increased the incidence of chromosome aberrations per cell in comparison with the initial level. The effect directly depends on the size of the halogen atom of thymidine.

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References

  1. V. I. Stobetskii,Byull. Eksp. Biol. Med.,112, No. 7, 72–73 (1991).

    CAS  Google Scholar 

  2. V. I. Stobetskii, —Ibid.,120, No. 9, 326–328 (1995).

    CAS  Google Scholar 

  3. G. Duckworth-Rysiecki, K. Cornish, C. A. Clarke, and M. Buchwald,Somat. Cell Mol. Genet.,11, 35–41 (1985).

    Article  PubMed  CAS  Google Scholar 

  4. P. G. Otto, P. A. Otto, and E. Therman,Chromosoma (Berlin),84, 337–344 (1981).

    Article  CAS  Google Scholar 

  5. M. S. Sasaki and A. Tonomura,Cancer Res.,33, 1829–1836 (1973).

    PubMed  CAS  Google Scholar 

  6. V. I. Stobetsky,Biol. Zbl.,97, 587–594 (1978).

    Google Scholar 

  7. C. A. Strathdee, A. M. V. Duncan, and M. Buchwald,Nature Genetics,1, 196–198 (1992).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Cytogenetics and Molecular Biology, Institute of Pediatric Hematology, Russian Ministry of Health, Moscow

    V. I. Stobetskii, A. N. Chebotarev, N. P. Kuleshov & E. V. Samochatova

  2. the Medical Industry, Moscow

    V. I. Stobetskii, A. N. Chebotarev, N. P. Kuleshov & E. V. Samochatova

Authors
  1. V. I. Stobetskii
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  2. A. N. Chebotarev
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  3. N. P. Kuleshov
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  4. E. V. Samochatova
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 4, pp. 464–466, April, 1996

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Stobetskii, V.I., Chebotarev, A.N., Kuleshov, N.P. et al. Halogen analogs of thymidine increase the level of chromosome aberrations in cells of patients with Fanconi's anemia. Bull Exp Biol Med 121, 424–425 (1996). https://doi.org/10.1007/BF02446748

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  • DOI: https://doi.org/10.1007/BF02446748

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