Abstract
Quinine and halidor, modifiers of multiple drug resistancein vitro, did not abolish tumor resistance to doxorubicinin vivo, as was shown in male hybrid BDF1 mice with transplanted leukemia P 388 sensitive to doxorubicin and with induced resistance to it. Induced hyperglycemia did not lead to the manifestation of a therapeutic effect of doxorubicin in mice with leukemia P 388 sensitive to the antibiotic and with induced resistance to it.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
F. V. Donenko, S. M. Sitdikova, and L. V. Moroz,Vopr. Onkol., No. 11-12, 1034–1041 (1991).
Z. P. Sofinaet al., eds.,Experimental Assessment of Antitumor Agents in the USSR and USA [in Russian], Moscow (1980).
B. Chauffert, H. Pelletier, C. Corda,et al., Br. J. Cancer,62, No. 3, 395–397 (1990).
H. Hamada and T. Tsuruo,J. Biol. Chem.,263, No. 7, 1454–1458 (1988).
H. L. Pearce, A. R. Safa, N. J. Bach,et al., Proc. Natl. Acad. Sci. USA,86, No. 13, 5128–5132 (1989).
M. Volm, T. Efferh, J. Matern, and E. M. Pommerenke,Arzneimittelforschung,42, No. 9, 1163–1168 (1992).
L. Wu, A. M. Smythe, S. F. Stinson,et al., Cancer Res.,52, No. 11, 3029–3034 (1992).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 4, pp. 459–461, April, 1996
Rights and permissions
About this article
Cite this article
Sitdikova, S.M., Donenko, F.V., Kabieva, A.O. et al. Use of multiple drug resistance modifiers to overcome tumor resistance to cytostatics in anin vivo system. Bull Exp Biol Med 121, 419–421 (1996). https://doi.org/10.1007/BF02446746
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02446746