Abstract
A panel of five monoclonal antibodies to surface antigens of small-cell pulmonary carcinoma was used for immunodiagnosis of metastases to the bone marrowin vitro in patients with small-cell carcinoma of the lungs. Standard cytomorphological diagnosis revealed metastases to the bone marrow in 6 out of 58 patients (10.3%). Using monoclonal antibodies, positive cells were detected in 12 (20.6%) patients, the tumor nature of the positive cells being undoubted in 7 preparations (12.6%). Five out of 6 cytologically positive cases were confirmed.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 4, pp. 456–458, April, 1996
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Goncharskaya, M.A., Orel, N.F., Perevodchikova, N.I. et al. In vitro detection of metastases of small-cell pulmonary carcinoma to the bone marrow using monoclonal antibodies. Bull Exp Biol Med 121, 416–418 (1996). https://doi.org/10.1007/BF02446745
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DOI: https://doi.org/10.1007/BF02446745