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Autoantibodies to human chorionic gonadotropin in habitual abortions

  • Microbiology and Immunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

An enzyme immunoassay is developed for detecting autoantibodies to human chorionic gonadotropin in the blood serum and a high incidence of these antibodies in women with a history of habitual abortions is demonstrated. A high level of autoantibodies is associated with threatened abortion, placental dysfunction, and hemostasis disorders. The results confirm the hypothesis regarding the production of autoantibodies to human chorionic gonadotropin as a possible autoimmune mechanism underlying habitual abortion.

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Authors and Affiliations

  1. Laboratory of Clinical Immunology, Department for the Prevention of Miscarriages, Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow

    I. V. Ponomareva, G. T. Sukhikh, E. B. Nikitin, P. A. Kiryushchenkov, V. M. Sidel'nikova & L. V. Van'ko

Authors
  1. I. V. Ponomareva
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  2. G. T. Sukhikh
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  3. E. B. Nikitin
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  4. P. A. Kiryushchenkov
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  5. V. M. Sidel'nikova
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  6. L. V. Van'ko
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 4, pp. 450–452, April, 1996

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Ponomareva, I.V., Sukhikh, G.T., Nikitin, E.B. et al. Autoantibodies to human chorionic gonadotropin in habitual abortions. Bull Exp Biol Med 121, 410–412 (1996). https://doi.org/10.1007/BF02446743

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  • DOI: https://doi.org/10.1007/BF02446743

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