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Substances increasing the extracellular content of dopamine in the striatum prevent the development of haloperidol catalepsy in rats

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effects of substances which raise the extracellular level of dopamine in the striatum (amphetamine, pargyline, nomifenzine, sulpiride, piracetam, and L-DOPA) on the intensity of haloperidol-induced catalepsy were studied in rats. It was shown that elevation of the extracellular content of dopamine in the striatum hindered the development of haloperidol catalepsy in rats.

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Authors and Affiliations

  1. Laboratory of Neurochemical Pharmacology, Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    R. R. Gainetdinov & K. S. Raevskii

Authors
  1. R. R. Gainetdinov
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  2. K. S. Raevskii
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 4, pp. 438–440, April, 1996

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Gainetdinov, R.R., Raevskii, K.S. Substances increasing the extracellular content of dopamine in the striatum prevent the development of haloperidol catalepsy in rats. Bull Exp Biol Med 121, 399–401 (1996). https://doi.org/10.1007/BF02446739

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  • DOI: https://doi.org/10.1007/BF02446739

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