Skip to main content
SpringerLink
Log in

Antiarrhythmic effects of μ-opiate receptor agonists in rats with epinephrine-induced arrhythmias: Role of the vegetative nervous system

  • General Pathology and Pathological Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The μ-opiate receptor agonists DAGO and DALDA preinjected intravenously in a dose of 0.1 mg/kg prevented the occurrence of arrhythmias in rats injected with epinephrine. Their antiarrhythmic activity was not modified by atropine or hexamethonium. It is concluded that the vegetative nervous system plays no substantial role in mediating the antiarrhythmic effects of DAGO and DALDA, and that these effects are most likely associated with stimulation of cardiac opiate receptors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. P. P. Denisenko, in:Gangliolytics and Blockers of Neuromuscular Synapses [in Russian], Leningrad (1958), pp. 21–49.

  2. Yu. B. Lishmanov and L. N. Maslov,Opioid Neuropeptides and Adaptive Protection of the Heart [in Russian], Tomsk (1994).

  3. B. K. Handa, A. C. Lane, J. A. H. Lord,et al., Eur. J. Pharmacol.,70, 531–540 (1981).

    Article  PubMed  CAS  Google Scholar 

  4. B. S. Kolman, R. L. Verrier, and B. Lown,Circulation,52, 578–585 (1975).

    PubMed  CAS  Google Scholar 

  5. L. N. Maslov and Yu. B. Lishmanov,Int. J. Cardiol.,40, 89–94 (1993).

    Article  PubMed  CAS  Google Scholar 

  6. M. J. Millan and F. C. Colpaert,Neuroscience,42, No. 2, 541–553 (1991).

    Article  PubMed  CAS  Google Scholar 

  7. W. Pardridge and L. Mietus,Endocrinology,109, No. 4, 1138–1143 (1981).

    Article  PubMed  CAS  Google Scholar 

  8. T. Podzuweit, G. C. Louw, and B. C. Shanley, in:Advances in Myocardiology, Baltimore (1980), Vol. 2, pp. 133–143.

  9. S. W. Rabkin,Life Sci.,45, 1039–1047 (1989).

    Article  PubMed  CAS  Google Scholar 

  10. P. W. Schiller, T. M.-D. Nguyen, N. N. Chung,et al., J. Med. Chem.,32, 698–703 (1989).

    Article  PubMed  CAS  Google Scholar 

  11. C. Ventura, L. Bastagli, P. Bernardi,et al., Biochim. Biophys. Acta,987, 69–74 (1989).

    Article  PubMed  CAS  Google Scholar 

  12. E. T. Wei, A. Lee, and J. K. Chang,Life Sci.,26, 1517–1522 (1980).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Experimental Cardiology, Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk

    L. N. Maslov, A. V. Krylatov & Yu. B. Lishmanov

Authors
  1. L. N. Maslov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. V. Krylatov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yu. B. Lishmanov
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 7, pp. 25–27, July, 1996

Rights and permissions

Reprints and permissions

About this article

Cite this article

Maslov, L.N., Krylatov, A.V. & Lishmanov, Y.B. Antiarrhythmic effects of μ-opiate receptor agonists in rats with epinephrine-induced arrhythmias: Role of the vegetative nervous system. Bull Exp Biol Med 122, 671–673 (1996). https://doi.org/10.1007/BF02446018

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02446018

Key Words

Search

Navigation