The involvement of endogenous myocardial opioid receptor agonists in mediating the cardioprotective effect of postconditioning was studied in a model of isolated Langendorff-perfused rat hearts. This phenomenon was found to occur using three sessions of reperfusion (30 sec) and ischemia (30 sec) at the end of a 45-min period of total ischemia. Studies using selective blockers of different opioid receptor subtypes, added to the perfusion solution at the beginning of the reperfusion period, showed that the resistance of the heart to the actions of ischemia-reperfusion in ischemic postconditioning are mediated by activation of δ1 opioid receptors. It is suggested that the mechanism of the cardioprotective phenomenon of postconditioning involves a significant role for endogenous opioids synthesized in the myocardium.
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 100, No. 12, pp. 1391–1398, December, 2014.
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Lasukova, T.V., Maslov, L.N. & Gorbunov, A.S. The Role of the Opioid System of the Myocardium in Mediating the Cardioprotective Effect of Postconditioning. Neurosci Behav Physi 46, 548–551 (2016). https://doi.org/10.1007/s11055-016-0275-0
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DOI: https://doi.org/10.1007/s11055-016-0275-0