Abstract
After separation of normal murine bone marrow cells in a Percoll density gradient cellular fractions with densities of 1.076 and 1.060 g/ml are capable of suppressing thein vitro growth of leukemia cells. The cytostatic activity of these fractions, however, does not surpass the level of antitumor antiproliferative activity intrinsic to intact bone marrow cells. These cells were found to be capable of joining the splenocytes, thymocytes, and lymph node cells in effector cytostatic cooperation and thus enhance the final antitumor effect.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, No 8, pp. 181–183, August, 1995
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Avdeev, I.V., Seledtsov, V.I., Prokopenko, I.V. et al. Antitumor activity of normal bone marrow cells. Bull Exp Biol Med 120, 826–828 (1995). https://doi.org/10.1007/BF02445965
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DOI: https://doi.org/10.1007/BF02445965