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Stimulation of proliferative activity of human natural killers (CD16+CD56+ cells) by recombinant interleukin-3in vitro

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The proliferative activity of human natural killers (CD16+CD56+ cells) in the presence of 100 and 1000 IU/ml human recombinant interleukin-3 is investigatedin vitro. It is shown that recombinant interleukin-3 reliably enhances natural killer proliferation, causing a 9–15.2-fold increase of3H-thymidine uptake by CD16+CD56+ cells both in complete culture medium and in conditioned medium. The effect of the factor is 3.9–6.4 and 3.6–8.9-fold more potent than that of recombinant interleukin-2 and granulocyte-macrophage colony-stimulating factor, respectively, in the same doses.

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Authors and Affiliations

  1. Laboratory of Immunochemistry, Gamaleya, Institute of Epidemiology and Microbiology, Moscow

    S. B. Cheknev

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  1. S. B. Cheknev
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No 4, pp. 409–412, April, 1995

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Cheknev, S.B. Stimulation of proliferative activity of human natural killers (CD16+CD56+ cells) by recombinant interleukin-3in vitro . Bull Exp Biol Med 119, 396–399 (1995). https://doi.org/10.1007/BF02445903

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  • DOI: https://doi.org/10.1007/BF02445903

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