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Sustained aftereffect of the amnestic action of scopolamine in rats and its elimination by piracetam

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Experiments were carried out on male Wistar rats to assess (1) the effect of chronically administered (for 20 days) scopolamine on their learning capacity and memory 10 days after its last administration and (2) the influence of the nootropic piracetam, given for 10 days after scopolamine and before learning a conditioned passive avoidance response, on cognitive functions of the brain altered as a result of the M-cholinergic receptors being blocked by scopolamine. Scopolamine-dosed rats showed poor reproduction of the conditioned passive avoidance response when tested for this response at 24 h and 30 days after learning it, whereas those treated with piracetam after scopolamine retained the response well both at 24 h and at 30 days. Piracetam also restored the scopolamine-impaired acute extinction of orienting/exploratory activity in the rats.

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Authors and Affiliations

  1. Laboratory of Psychopharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    R. U. Ostrovskaya, F. A. Firova & S. S. Trofimov

Authors
  1. R. U. Ostrovskaya
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  2. F. A. Firova
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  3. S. S. Trofimov
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No 4, pp. 372–374, April, 1995

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Ostrovskaya, R.U., Firova, F.A. & Trofimov, S.S. Sustained aftereffect of the amnestic action of scopolamine in rats and its elimination by piracetam. Bull Exp Biol Med 119, 359–361 (1995). https://doi.org/10.1007/BF02445892

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  • DOI: https://doi.org/10.1007/BF02445892

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