Skip to main content
SpringerLink
Log in

Effect of lymphokines on platelet-mediated cytotoxicity

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of several cytokines on the cytolytic activity of platelets from healthy donors was studied. A human lung adenocarcinoma cell line served as the source of targets. IL-1α and IL-1β in a dose range of 10–100 U/ml increased the activity of initially lowtoxic platelets, and vice versa. An increase of the dose of any cytokine up to 1000 U/ml caused inhibition of cytolysis, irrespective of the initial cytotoxicity of platelets. Unlike the mentioned cytokines, tumor necrosis factor by itself produced a cytotoxic effect on the targets; however, it had no effect on the cytolytic activity of platelets.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. S. N. Bykovskaya, N. G. Blokhina, D. L. Speranskii, and T. A. Kupriyanova,Byull. Eksp. Biol. Med.,105, No 6, 708–709 (1988).

    Article  Google Scholar 

  2. G. N. Prizhivoit,Vopr. Onkol., No 3, 46 (1964).

    Google Scholar 

  3. S. N. Bykovskaya, A. V. Bolvacheva, M. V. Kiselevsky, and V. A. Khalenko,Biomed. Pharmacother.,45, 279–288 (1991).

    Article  PubMed  CAS  Google Scholar 

  4. K. L. Deyerle, J. E. Sims, S. K. Dower, and M. A. Bothwell,J. Immunol.,149, 1657–1665 (1992).

    PubMed  CAS  Google Scholar 

  5. G. A. Grethen, N. E. Kay, and R. J. Johnson,Blood,65, 1252 (1985).

    Google Scholar 

  6. K. Onosaki, K. Matsushima, B. B. Aggawal, and J. J. Oppenheim,J. Immunol.,135, 3962–3968 (1985).

    Google Scholar 

  7. K. Shimoda, S. Okamura, N. Harada,et al., J. Clin. Invest.,91, 1310–1313 (1993).

    Article  PubMed  CAS  Google Scholar 

  8. A. Tingstrom, C. Reuterdahl, C. Lindahl, and C. H. Heldin,J. Immunol.,148, 546–548 (1992).

    PubMed  CAS  Google Scholar 

  9. X. Q. Yan, G. Brady, and N. N. Iscove,,150, 2440–2448 (1993).

    PubMed  CAS  Google Scholar 

  10. M. N. Zheng, D. J. Wood, and J. M. Papadimitriou,Pathol. Res. Pract.,188, 1104–1121 (1992).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cancer Research Center, Russian Academy of Medical Sciences, Moscow

    N. V. Malakhova, M. V. Kiselevskii, D. N. Cherepovskii & S. N. Bykovskaya

  2. Sechenov Medical Academy, Moscow

    A. A. Vorob'ev

Authors
  1. N. V. Malakhova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. V. Kiselevskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. N. Cherepovskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. A. Vorob'ev
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. N. Bykovskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No. 3, pp. 320–323, March, 1995

Rights and permissions

Reprints and permissions

About this article

Cite this article

Malakhova, N.V., Kiselevskii, M.V., Cherepovskii, D.N. et al. Effect of lymphokines on platelet-mediated cytotoxicity. Bull Exp Biol Med 119, 312–315 (1995). https://doi.org/10.1007/BF02445846

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02445846

Key Words

Search

Navigation