Abstract
The role of fibroblasts in the differentiation of the epidermis and its relationships with other somatic cells, specifically, keratinocytes, are studied using a skin equivalent formed from various types of fibroblasts separated from thoracic skin of a healthy donor, apparently healthy skin sites and plaques from a patient with psoriasis, keloids and upper eyelid skin of a normal subject, and keratinocytes separated from the umbilical skin of a newborn. Fibroblasts are shown to be active participants in the differentiation and formation of epidermis specificity. Various types of fibroblasts form a histologically different skin equivalent possessing the specific properties of the epidermis of the skin sites from which they were isolated.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
E. Bell, S. Sher, B. Hull,et al., J. Invest. Dermatol.,81, 2S-10S (1983).
M. S. Kristensen, K. Paludan, and C. G. Larsen, —Ibid.,97, 506–510 (1991).
J. G. Krueger, J. F. Krane, D. M. Carter, and A. B. Gotlieb, —Ibid.,94, 135 (1990).
C. G. Larsen, A. O. Anderson, J. J. Oppenheim, and K. Matsushima,Immunology,68, 31–36 (1989).
D. Y. M. Leung, P. Walsh, R. Giorno, and D. A. Norris,J. Invest. Dermatol.,100, No 3, 225–228 (1993).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No 1, pp. 80–84, January, 1996
Rights and permissions
About this article
Cite this article
Konstantinova, N.V., Urso, R.D., Korotkii, N.G. et al. Role of fibroblasts as the principal factor in differentiation of the epidermis. Bull Exp Biol Med 121, 72–76 (1996). https://doi.org/10.1007/BF02445711
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02445711