Abstract
Somatoliberin stimulates secretion of growth hormone and has no effect on secretion of prolactin in primary cultures of hypophyseal adenoma cells obtained from acromegalic patients. A short-term contact of the cells with somatostatin inhibits secretion of growth hormone, while a long-term contact with this hormone inhibits prolactin production. Somatoliberin abolishes the inhibitory effect of somatostatin on the growth hormone secretion and at high concentrations stimulates it.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 3, pp. 323–326, March, 1997
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Komolov, I.S., Bulatov, A.A., Osipova, T.A. et al. Secretory reactions of cultured hypophyseal growth hormone-producing adenoma cells to somatoliberin and somatostatin. Bull Exp Biol Med 123, 279–282 (1997). https://doi.org/10.1007/BF02445426
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DOI: https://doi.org/10.1007/BF02445426