Skip to main content
SpringerLink
Log in

Inhibition of human plasma ApoB-lipoproteins

  • Biophysics and Biochemistry
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effects of astaxanthine and β-carotene on the oxidation of isolated human plasma apoB-lipoproteins induced by copper ions or hemin/hydrogen peroxide are studied. Astaxanthine inhibits the formation of both primary (diene conjugates) and secondary (thiobarbituric acid-reactive substances) products of lipid perioxidation. Antioxidant activity of astaxanthine is observed in the concentration range 20–100 μg/mg protein of apoB-lipoproteins. The antioxidant activity of astaxanthine is higher than that of β-carotene.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. A. Beuge and S. D. Aust,Methods Enzymol.,52, 302–310 (1978).

    Google Scholar 

  2. M. Bradford,Anal. Biochem.,72, 248–254 (1976).

    Article  PubMed  CAS  Google Scholar 

  3. M. Burstein and H. R. Scholnick,Adv. Lipid Res.,11, 67–108 (1973).

    PubMed  CAS  Google Scholar 

  4. J. M. Gaziano, A. Hatta, M. Flynn,et al., Atherosclerosis,112, 187–195 (1995).

    Article  PubMed  CAS  Google Scholar 

  5. S. Gerber and D.-P. Haeder,FEMS Microbiol. Ecol.,13, 177–184 (1994).

    Article  CAS  Google Scholar 

  6. R. Grangaud and R. Massoned,Bull. Soc. Chim. Biol.,31, 231 (1949).

    CAS  Google Scholar 

  7. H. Jyonoushi, S. Sun, and M. Cross,Nutr. Cancer,23, 171–183 (1994).

    Article  Google Scholar 

  8. N. I. Krinski,Proc. Soc. Exp. Biol. Med.,200, 248–254 (1992).

    Google Scholar 

  9. F. Lu, A. Vonshak, and S. Bossiba,J. Psychol.,30, 829–833 (1994).

    Google Scholar 

  10. I. Nishigaki, W. Miki, A. A. Dmitrovskii, and K. Yagi,J. Clin. Biochem. Nutr.,16, 161–166 (1994).

    CAS  Google Scholar 

  11. W. A. Schroeder and E. A. Jonson,J. Gen. Microbiol.,139, 907–912 (1993).

    CAS  Google Scholar 

  12. O. Syunji, F. Ojima, H. Sakamoto,et al., J. Nutr. Sci. Vitaminol. (Tokyo),39, 607–615 (1993).

    Google Scholar 

  13. J. L. Witztum and D. Steinberg,J. Clin. Invest.,88, 1785–1792 (1991).

    Article  PubMed  CAS  Google Scholar 

  14. S. Yla-Herttuala,Ann. Med.,23, 561–567 (1991).

    PubMed  CAS  Google Scholar 

  15. L. W. Yu, L. Latriano, S. Duncan,et al., Anal. Biochem.,156, 326–330 (1986).

    Article  PubMed  CAS  Google Scholar 

  16. J. Terao,Lipids,24, 659–661 (1989).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Extracorporeal Therapy, A. L. Myasnikov Institute of Clinical Cardiology, Cardiology Research Center, Academy of Medical Sciences, Moscow

    V. V. Kukharchuk & I. F. Chernyad'eva

  2. Laboratory of Vitamins and Physiologically Active Compounds, A. N. Bakh Institute of Biochemistry, Russian Academy of Sciences, Moscow

    K. B. Shumaev, A. A. Dmitrovskii & B. Ya. Bykhovskii

Authors
  1. V. V. Kukharchuk
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. B. Shumaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. A. Dmitrovskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I. F. Chernyad'eva
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. B. Ya. Bykhovskii
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 3, pp. 285–288, March, 1997

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kukharchuk, V.V., Shumaev, K.B., Dmitrovskii, A.A. et al. Inhibition of human plasma ApoB-lipoproteins. Bull Exp Biol Med 123, 248–250 (1997). https://doi.org/10.1007/BF02445415

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02445415

Key Words

Search

Navigation