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Reaction of C-reactive protein with interleukin-2 receptor α-Chain

  • Microbiology and Immunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Study of the mechanism of mutagenic effect of C-reactive protein, the major reactant of acute phase inflammation, showed that this protein is mitogenic for normal lymphocytes and inhibits proliferation of interleukin-2-dependent CTLL-2 cells in the presence of interleukin-2; antibodies to α-chain of interleukin-2 receptor abolish the inhibitory effect of C-reactive protein. High-affinity receptor of interleukin-2 may be assembled by interleukin-2 or C-reactive protein, but not by both ligands. Therefore, immunoregulatory effects of C-reactive protein are different during the acute phase of inflammation and remote periods of immune response. At the early stages, when the production of interleukin-2 is negligible, C-reactive protein can act as a mitogen inducing polyclonal activation of lymphocytes, while later it acts as a factor limiting clonal expansion of committed immunocompetent cells.

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Authors and Affiliations

  1. Department of Immunology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg

    P. G. Nazarov

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  1. P. G. Nazarov
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 6, pp. 657–660, June, 1998

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Nazarov, P.G. Reaction of C-reactive protein with interleukin-2 receptor α-Chain. Bull Exp Biol Med 125, 582–584 (1998). https://doi.org/10.1007/BF02445246

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  • DOI: https://doi.org/10.1007/BF02445246

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