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Psychotropic activity of cholecystokinine tetrapeptide analogs

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Psychotropic activity of two cholecystokinin analogs Trp-R1-Asp-Phe-NH2 and R2-Trp-R3-Asp-Phe-NH2 is studied using behavioral tests. Both analogs have no effect on motor activity. Trp-R1-Asp-Phe-NH2 in doses of 0.1 and 0.3 mg/kg exhibits anxiogenic activity and impairs learning (only in a dose of 0.1 mg/kg) of experimental animals. R2-Trp-R3-Asp-Phe-NH2 possesses no anxiogenic activity and in doses of 0.1 and 0.3 mg/kg promotes learning, which attests to its nootropic activity.

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Authors and Affiliations

  1. Research Center of Addiction, Russian Cardiology Research-and Production Center, Ministry of Health, Moscow

    I. P. Anokhina, Zh. D. Bespalova, T. V. Proskuryakova, N. V. Pankratova, M. E. Pal'keeva & O. B. Petrichenko

Authors
  1. I. P. Anokhina
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  2. Zh. D. Bespalova
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  3. T. V. Proskuryakova
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  4. N. V. Pankratova
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  5. M. E. Pal'keeva
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  6. O. B. Petrichenko
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 6, pp. 647–650, June, 1998

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Anokhina, I.P., Bespalova, Z.D., Proskuryakova, T.V. et al. Psychotropic activity of cholecystokinine tetrapeptide analogs. Bull Exp Biol Med 125, 573–575 (1998). https://doi.org/10.1007/BF02445243

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  • DOI: https://doi.org/10.1007/BF02445243

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