Abstract
Immunomodulating effect of salmozan injected at different times of the day was assessed by changes in 5-nucleotidase activity of mouse peritoneal macrophages. The effect of the immunomodulator correlates with the level of 5-nucleotidase activity in control animals. When this value was high in the control, it was decreased in experimental rats, and vice versa. The effect of the immunomodulator on the enzyme activity and on immune and neuroendocrine parameters is governed by the “mirror symmetry” principle.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
A. P. Dubrov,Symmetry of Biorhythms and Reactivity [in Russian], Moscow (1987).
G. B. Kirillicheva, I. G. Baturina, V. V. Mit'kin,et al., Byull. Eksp. Biol. Med.,115, No. 6, 519–521 (1993).
G. B. Kirillicheva, I. G. Baturina, K. K. Rozhkov, and M. A. Ignatenko,, No. 3, 282–284 (.
G. B. Kirillicheva, V. A. Bekhalo, M. S. Solov'eva,et al., in:Immunomodulators in Infectious Pathology [in Russian], Moscow (1988), pp. 105–108.
G. B. Kirillicheva, A. V. Naumov, T. M. Taranenko,et al., Byull. Eksp. Biol. Med.,113, No. 3, 297–299 (1992).
G. B. Kirillicheva, M. S. Solov'eva, I. G. Baturina, and M. A. Tumanyan,,115, No. 5, 642–645 (1993).
M. A. Tumanyan and G. B. Kirillicheva,Byull. Izobret., No. 6 (1986).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 12, pp. 658–662, December, 1997
Rights and permissions
About this article
Cite this article
Kirillicheva, G.B., Solov'eva, M.S., Baturina, I.G. et al. Immunomodulating effect of salmozan injected at different times of the day. Bull Exp Biol Med 124, 1206–1210 (1997). https://doi.org/10.1007/BF02445121
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02445121