Abstract
The inbred rat strains WAG and Fischer-344 were found to differ in the duration of amphetamine-induced stereotypy and the degree of hyperthermy elicited by this drug, the stereotypy lasting longer in WAG rats and the hyperthermy being more pronounced in Fischer—344 rats. A comparison of interstrain differences in the amphetamine effects, in receptor binding, and in the pharmacological activity of receptor agonists suggests that the μ-opiate system of the brain may be involved in the manifestation of amphetamine-induced stereotypy, while its serotoninergic system may mediate the elevation of body temperature caused by this drug.
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References
S. C. Gerfin and R. J. Baldessarini,Life Sci.,27, 1435 (1980).
R. Kucznenski, in:Stimulants: Neurochemical, Behavioral and Clinical Perspectives (I. Cres, Ed.), New York (1983), p. 31.
P. V. Piazza, G. M. Deminieri, M. Le Moal, and H. Simon,Science,245, 1511–1513 (1989).
D. S. Segal,J. Pharmacol. Exp. Ther.,122, 137 (1987).
P. Soubrie, T. D. Reisine, and J. Glowinski,Neuroscience,13, 605 (1984).
S. K. Sudakov, R. S. Goldberg, E. V. Borisova,et al., Psychopharmacology,112, 183–188 (1993).
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, No 9, 242–243, September, 1995
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Tyurina, I.V., Sudakov, S.K. Participation of opioid and serotoninergic brain receptors in amphetamine-induced stereotypy and hyperthermy. Bull Exp Biol Med 120, 881–883 (1995). https://doi.org/10.1007/BF02445004
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DOI: https://doi.org/10.1007/BF02445004