Abstract
Effects caused by the chronic administration of Parlodel on the development of behavioral signs of depression in rats are studied using the new model of depressive syndrome induced by the systemic administration of MPTP. Pretreatment with Parlodel prevents locomotor depression, weight loss, reduction of liquid intake, a decline of the preference of sucrose solution over water, and a rise of the depression index and promotes a quicker restoration of exploratory activity, i.e., it safeguards rats from manifestating the behavioral signs of MPTP-induced depression.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, No 7, pp. 66–70, July, 1995
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Krupina, N.A., Orlova, I.N. & Kryzhanovskii, G.N. Effect of parlodel on the development of a depressive syndrome induced by administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in rats. Bull Exp Biol Med 120, 712–716 (1995). https://doi.org/10.1007/BF02444669
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DOI: https://doi.org/10.1007/BF02444669