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Study of the hemostatic properties of gaseous ozone

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The hemostatic properties of ozone were studied on models of parenchymatous (from a wound in the liver) and stem (from the stump of the tail) bleedings in rats. An air-ozone mixture at a flow rate of 1 liter/min and a concentration of 2 mg/ml was found to exert a pronounced hemostatic effect. Our findings indicate that the arrest of bleeding under the influence of ozone is due to the formation of a fibrin membrane on the surface of the flowing blood, this leading to rapid and effective hemostasis. Preliminary drying of the wound still further speeds the onset of hemostasis.

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Authors and Affiliations

  1. State Center for Surgical Dressings, Sutures, and Polymer Materials, A. V. Vishnevskii Institute of Surgery, Russian Academy of Medical Sciences, Moscow

    Yu. P. Kashperskii, A. A. Adamyan, V. A. Makarov, S. P. Glyantsev & V. A. Zhukov

  2. Department of Pathology and Pharmacology of Hemostasis, Hematology Research Center, Russian Academy of Medical Sciences, Moscow

    Yu. P. Kashperskii, A. A. Adamyan, V. A. Makarov, S. P. Glyantsev & V. A. Zhukov

Authors
  1. Yu. P. Kashperskii
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  2. A. A. Adamyan
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  3. V. A. Makarov
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  4. S. P. Glyantsev
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  5. V. A. Zhukov
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120 No 7 pp. 62–65, July, 1995

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Kashperskii, Y.P., Adamyan, A.A., Makarov, V.A. et al. Study of the hemostatic properties of gaseous ozone. Bull Exp Biol Med 120, 708–711 (1995). https://doi.org/10.1007/BF02444668

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  • DOI: https://doi.org/10.1007/BF02444668

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