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Potential for correcting syndromal metabolic disorders by means of enzyme therapy

  • Pathological Physiology and General Pathology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Measurement of metabolites in the cardiac muscle of rabbits at different stages of myocardial infarction showed elevated levels of intermediate metabolic products with marked acidic properties in the infarcted area as well as in the adjacent and more distant (apparently intact) areas. Introduction of exogenous lactate dehydrogenase into the circulation led to enhanced metabolic processes in the cytoplasm and mitochondria of cardiac and skeletal muscle cells. This suggests that lactate dehydrogenase may be recommended for use as an agent helping to normalize oxidative processes, compensate for energy deficiency, and correct metabolism in tissues.

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Authors and Affiliations

  1. Department of Biological and Clinical Chemistry, State Medical Institute, Samara

    F. N. Gil'miyarova, V. Yu. Golenishchev & V. M. Radomskaya

Authors
  1. F. N. Gil'miyarova
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  2. V. Yu. Golenishchev
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  3. V. M. Radomskaya
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, No 7, pp. 23–25, July, 1995

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Gil'miyarova, F.N., Golenishchev, V.Y. & Radomskaya, V.M. Potential for correcting syndromal metabolic disorders by means of enzyme therapy. Bull Exp Biol Med 120, 668–670 (1995). https://doi.org/10.1007/BF02444655

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  • DOI: https://doi.org/10.1007/BF02444655

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