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Changes in the ultrastructure of human erythrocytes and in their content of free fatty acids during incubation with hydroperoxide and calcium ionsin vitro

  • Morphology and Pathomorphology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

It is shown that incubation of a suspension of human erythrocytes with H2O2 and Ca2+ mainly results in echinocytic transformation and hemolysis; incubation with H2O2 in the absence of Ca2+ is attended by polymorphous changes in erythrocytes: discocyte swelling, formation of stomatocytes and echinocytes and their hemolysis. The level of free fatty acids in human erythrocytes increases for incubation with Ca2+ and calcimycin under anaerobic conditions and drops for H2O2-induced activation of lipid peroxidation.

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Authors and Affiliations

  1. Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow

    V. I. Sorokovoi, G. M. Nikitina, A. G. Lapinskii & N. N. Mochenova

Authors
  1. V. I. Sorokovoi
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  2. G. M. Nikitina
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  3. A. G. Lapinskii
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  4. N. N. Mochenova
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 8 pp. 207–211, August, 1994

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Sorokovoi, V.I., Nikitina, G.M., Lapinskii, A.G. et al. Changes in the ultrastructure of human erythrocytes and in their content of free fatty acids during incubation with hydroperoxide and calcium ionsin vitro . Bull Exp Biol Med 118, 905–909 (1994). https://doi.org/10.1007/BF02444461

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  • DOI: https://doi.org/10.1007/BF02444461

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