Abstract
The tumorigenicity of cell clones derived from fibroblast lines isolated from colon cancer xenografts is studied in thymus-free animals. During cloning of the cell line obtained from the 3rd passage of the xenograft about 20% of the clones proved to be nontumorigenic, whereas such cells were not found in the line obtained from the 89th passage. Cytogenetic analysis of nontumorigenic clones revealed monosomy for the 13th chromosome with no alterations in the other chromosome pairs. Hybridization for the presence of Alu sequences was negative.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 8, pp. 184–187, August, 1994
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Bryzgalov, I.P., Galetskii, S.A., Yudicheva, T.V. et al. Different tumorigenicity of cell clones derived from stromal fibroblasts of human colon cancer xenografts. Bull Exp Biol Med 118, 879–882 (1994). https://doi.org/10.1007/BF02444455
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DOI: https://doi.org/10.1007/BF02444455