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Effects of various human interleukin-2 preparations and lymphokine-activated killer cells on the production of antibodies in micein vivo and of human immunoglobulinsin vitro

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Comparison of the lymphocytic IL-2 (lIL-2, lymphokinin) and recombinant IL-2 (rIL-2) showed that lIL-2 is characterized by a more pronounced stimulating effect of low doses on antibody production in mice and on human immunoglobulin production. High doses of lIL-2, in contrast to rIL-2, do not cause hyperstimulation of antibody production or immunoglobulin production. Human lymphokine-activated killer (LAK) cells, induced by rIL-2in vitro during 7 but not 3 days, enhance the production of human immunoglobulins. Monocytes activated by rIL-2 suppress the stimulating effect of LAK cells on immunoglobulin production.

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References

  1. M. P. Potapnev and N. N. Voitenok,Immunologiya, No 6, 61–65 (1983).

    Google Scholar 

  2. M. P. Potapnev, V. D. Zobnin, and E. V. Ruksha., No 3, 23–26 (1991).

    Google Scholar 

  3. M. P. Potapnev and D. V. Pechkovskii,Byull. Eksp. Biol. Med.,114, No 12, 641–643 (1992).

    CAS  Google Scholar 

  4. N. N. Trapeznikov, V. V. Yavorskii, A. B. Syrkin,et al., Vestn. Vsesoyuz. Onkol. Nauch. Tsentra, No 1, 31–34 (1990).

    Google Scholar 

  5. L. A. Aarden, E. R. De Groot, O. L. Scharp,et al., Europ. J. Immunol.,17, 1411–1416 (1987).

    CAS  Google Scholar 

  6. S. J. Hopkins and M. Humphrey,J. Immunol. Meth.,120, No 2, 271–276 (1989).

    Article  CAS  Google Scholar 

  7. G. Kaplan, Z. A. Cohn, and K. A. Smith,Biotechn. Bioeng.,10, 157–162 (1992).

    CAS  Google Scholar 

  8. A. O'Garra, S. Umland, T. De France, and J. Christiansen,Immunol. Today,9, No 2, 45–54 (1988).

    Article  PubMed  Google Scholar 

  9. R. C. Rees and R. H. Wiltrout,,11, No 2, 36–38 (1990).

    Article  PubMed  CAS  Google Scholar 

  10. F. W. Ruscetti, in:Immunophysiology. The Role of Cells and Cytokines in Immunity and Inflammation, Eds. J. J. Oppenheim and E. M. Shevach, Oxford (1990), pp. 46–66.

  11. H. Suzuki, N. Yamashita, M. Maruyama,et al., Clin. Exp. Immunol.,78, 406–411 (1989).

    PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Research Institute of Hematology and Blood Transfusion, Ministry of Health of Belarus, Minsk

    M. P. Potapnev, T. S. Garbuzenko, A. V. Voznyuk, E. V. Ruksha, O. V. Shadrin & S. N. Bykovskaya

  2. Oncological Research Center, Russian Academy of Medical Sciences, Moscow

    M. P. Potapnev, T. S. Garbuzenko, A. V. Voznyuk, E. V. Ruksha, O. V. Shadrin & S. N. Bykovskaya

Authors
  1. M. P. Potapnev
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  2. T. S. Garbuzenko
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  3. A. V. Voznyuk
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  4. E. V. Ruksha
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  5. O. V. Shadrin
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  6. S. N. Bykovskaya
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 8, pp. 171–173, August, 1994

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Potapnev, M.P., Garbuzenko, T.S., Voznyuk, A.V. et al. Effects of various human interleukin-2 preparations and lymphokine-activated killer cells on the production of antibodies in micein vivo and of human immunoglobulinsin vitro . Bull Exp Biol Med 118, 865–868 (1994). https://doi.org/10.1007/BF02444451

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  • DOI: https://doi.org/10.1007/BF02444451

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