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Dose-dependent influence of buprenorphine on the phospholipid composition of cat hepatocyte plasma membranes in hemorrhagic shock

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

It is established that buprenorphine (0.3 mg/kg) induces considerable alterations in the phospholipid composition of hepatocyte plasma membranes as a result of phosphatidylserine accumulation and a considerable loss of sphingomyelin and lysophosphatidylserine. When administered in a dose of 0.03 mg/kg, buprenorphine facilitates normalization of the phosphoinositol turnover in hepatocyte plasma membranes.

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Authors and Affiliations

  1. Laboratory of Pathophysiology of Shock, Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences, Moscow

    G. F. Leskova & V. I. Udovichenko

Authors
  1. G. F. Leskova
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  2. V. I. Udovichenko
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 8, pp. 164–165, August, 1994

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Leskova, G.F., Udovichenko, V.I. Dose-dependent influence of buprenorphine on the phospholipid composition of cat hepatocyte plasma membranes in hemorrhagic shock. Bull Exp Biol Med 118, 856–858 (1994). https://doi.org/10.1007/BF02444448

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  • DOI: https://doi.org/10.1007/BF02444448

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