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Antiulcerogenic effects of benzylpenicillin in acutely stressed rats

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The antibiotic benzylpenicillin was found to produce dose-dependent antiulcerogenic effects in rats when administered immediately before their exposure to acute stress (swimming for 1 h) that led to gastric mucosal ulceration. Such effects were not observed in rats given benzylpenicillin 48 h before stress exposure. The results of this study suggest that in acutely stressed animals benzylpenicillin may activate as yet unidentified mechanisms which afford protection to the gastric mucosa and which are not associated with the longer-lasting antimicrobial effects of this antibiotic.

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Authors and Affiliations

  1. Chair of Human and Animal Physiology, Department of Biology, Moscow State University, Moscow, USSR

    A. V. Kaluev, G. E. Samonina & I. P. Ashmarin

Authors
  1. A. V. Kaluev
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  2. G. E. Samonina
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  3. I. P. Ashmarin
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 8, pp. 131–133, August, 1994

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Kaluev, A.V., Samonina, G.E. & Ashmarin, I.P. Antiulcerogenic effects of benzylpenicillin in acutely stressed rats. Bull Exp Biol Med 118, 818–820 (1994). https://doi.org/10.1007/BF02444437

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  • DOI: https://doi.org/10.1007/BF02444437

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