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Implication of the hippocampus in the development of a pain syndrome in rats following sciatic nerve damage

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Local destruction or electrostimulation of the hippocampus did not affect pain sensitivity thresholds in rats with intact sciatic nerve. In rats with transected sciatic nerve, local hippocampal damage accelerated the development of a pain syndrome considerably, while hippocampal electrostimulation delayed it so that 80% of the test rats did not appear to have been experiencing pain throughout the 45-day observation period.

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Authors and Affiliations

  1. Laboratory for Pathophysiology of Pain, Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences, Moscow

    M. L. Kukushkin, G. N. Kryzhanovskii, V. S. Smirnova, V. A. Zinkevich & V. K. Reshetnyak

Authors
  1. M. L. Kukushkin
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  2. G. N. Kryzhanovskii
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  3. V. S. Smirnova
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  4. V. A. Zinkevich
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  5. V. K. Reshetnyak
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 8, pp. 120–122, August, 1994

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Kukushkin, M.L., Kryzhanovskii, G.N., Smirnova, V.S. et al. Implication of the hippocampus in the development of a pain syndrome in rats following sciatic nerve damage. Bull Exp Biol Med 118, 806–809 (1994). https://doi.org/10.1007/BF02444433

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  • DOI: https://doi.org/10.1007/BF02444433

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