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Potentiating effect of thyrotropin-releasing hormone and of its synthetic analog digipramine on morphine-induced analgesia

  • Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Thyrotropin-releasing hormone (TRH) and its synthetic analog digipramine (DP) shortened the latency of the tail-flick response in mice when injected intraperitoneally in a dose of 5 mg/kg and to potentiate significantly the analgesic action of morphine. Possible mechanisms of these two effects and prospects for their medical use are discussed.

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Authors and Affiliations

  1. Chair of Human and Animal Physiology, Department of Biology, Moscow State University, Moscow, USSR

    A. A. Guseva, I. E. Gurskaya, P. Ya. Romanovskis & I. P. Ashmarin

Authors
  1. A. A. Guseva
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  2. I. E. Gurskaya
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  3. P. Ya. Romanovskis
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  4. I. P. Ashmarin
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 8, pp. 117–119, August, 1994

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Guseva, A.A., Gurskaya, I.E., Romanovskis, P.Y. et al. Potentiating effect of thyrotropin-releasing hormone and of its synthetic analog digipramine on morphine-induced analgesia. Bull Exp Biol Med 118, 803–805 (1994). https://doi.org/10.1007/BF02444432

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  • DOI: https://doi.org/10.1007/BF02444432

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