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Anti-ischemic effect of a new oxynicotinic acid derivative

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of a new derivative of oxynicotinic acid (KONA) on experimental cerebral ischemia is examined in rats. It is demonstrated that a single dose of the preparation (30 mg/kg) significantly decreases the severity of ischemic damage and increases the survival of the animals after bilateral ligation of the common carotid arteries. Comparison with xanthinol-nicotinate shows the advantages of the new preparation. Although KONA does not inhibit free-radical oxidationin vitro, it does lower the content of free-radical oxidation products in rat blood plasma to the normal level.

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Authors and Affiliations

  1. Institute of Neurology, Russian Academy of Medical Sciences, Moscow

    T. V. Ryasina, T. S. Korshunova, N. B. Polyanskii & K. O. Muranov

  2. N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow

    T. V. Ryasina, T. S. Korshunova, N. B. Polyanskii & K. O. Muranov

Authors
  1. T. V. Ryasina
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  2. T. S. Korshunova
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  3. N. B. Polyanskii
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  4. K. O. Muranov
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 7, pp. 49–51, July, 1994

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Ryasina, T.V., Korshunova, T.S., Polyanskii, N.B. et al. Anti-ischemic effect of a new oxynicotinic acid derivative. Bull Exp Biol Med 118, 731–733 (1994). https://doi.org/10.1007/BF02444371

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  • DOI: https://doi.org/10.1007/BF02444371

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