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Characterization of cardiac function in hypertensive rats of the NISAG strain (an ECG study)

  • Pathological Physiology and General Pathology
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Abstract

Analysis of ECGs recorded in 3 standard leads, 3 augmented limb leads, and 3 chest leads revealed typical signs of left ventricular hypertrophy with a relative deterioration of coronary blood supply in NISAG rats, a new strain with hereditary arterial hypertension. These signs are considered to be characteristic of an established arterial hypertension and may be taken as evidence that the NISAG strain can serve as an adequate animal model of human hypertensive disease.

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Authors and Affiliations

  1. Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk

    G. S. Yakobson, D. G. Sakharov & A. L. Markel'

Authors
  1. G. S. Yakobson
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  2. D. G. Sakharov
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  3. A. L. Markel'
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 7 pp. 17–18, July, 1994

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Yakobson, G.S., Sakharov, D.G. & Markel', A.L. Characterization of cardiac function in hypertensive rats of the NISAG strain (an ECG study). Bull Exp Biol Med 118, 695–697 (1994). https://doi.org/10.1007/BF02444359

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  • DOI: https://doi.org/10.1007/BF02444359

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