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Antiseizure and neurotoxic effects of various combinations of phenobarbital, diazepam, sodium valproate and 1,4-dihydropyridine riodipin

  • Pathological Physiology and General Pathology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The use of different anticonvulsants as 2-, 3-, or 4-member combinations considerably potentiates their antiseizure effects and, though to a lesser degree, increases their neurotoxicity. In most of these combinations the therapeutic index is considerably higher than in the case of individual preparations.

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Authors and Affiliations

  1. Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences, Moscow

    M. N. Karpova, G. N. Kryzhanovskii & I. Yu. Abrosimov

Authors
  1. M. N. Karpova
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  2. G. N. Kryzhanovskii
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  3. I. Yu. Abrosimov
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 7, pp. 14–16, July, 1994

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Karpova, M.N., Kryzhanovskii, G.N. & Abrosimov, I.Y. Antiseizure and neurotoxic effects of various combinations of phenobarbital, diazepam, sodium valproate and 1,4-dihydropyridine riodipin. Bull Exp Biol Med 118, 692–695 (1994). https://doi.org/10.1007/BF02444358

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  • DOI: https://doi.org/10.1007/BF02444358

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