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Effect of neonatal blood serum on the early stages of mouse embryogenesisin vitro

  • Physiology
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Abstract

The effect of blood sera from newborns delivered after complicated pregnancy and abnormal labor (CPAL) on 4-cell mouse embryos is studied. The embryos develop normally in the control sera, 78–100% of them reach the blastocyst stage, the mean number of blastomeres per embryo varies from 68 to 88 cells, and the mortality rate is 3–7%. The CPAL sera have an almost 100% embryolethal effect. The development of mouse embryos is markedly delayed. The most potent pathological effect is elicited by the sera of newborns whose mothers suffered from hypoxia.

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Authors and Affiliations

  1. Department of Molecular Genetics, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg

    I. B. Arkhangel'skaya, V. I. Shtil'bans, N. A. Chebotar' & A. M. Kotin

Authors
  1. I. B. Arkhangel'skaya
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  2. V. I. Shtil'bans
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  3. N. A. Chebotar'
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  4. A. M. Kotin
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 7, pp. 6–7, July, 1994

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Arkhangel'skaya, I.B., Shtil'bans, V.I., Chebotar', N.A. et al. Effect of neonatal blood serum on the early stages of mouse embryogenesisin vitro . Bull Exp Biol Med 118, 683–685 (1994). https://doi.org/10.1007/BF02444355

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  • DOI: https://doi.org/10.1007/BF02444355

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