Abstract
Newborn rats were born of females exposed to high-altitude hypoxia. Pregnant females were injected i.p. either nonopiate leu-enkephalin analog or hydra peptide morphogen 10 μg/kg 30 min prior to being placed in a pressure chamber. Prenatal hypoxia causes the inhibition of the proliferative processes in tracheal epithelium and activation of lipid peroxidation (LPO) in lungs of newborn rats. The administration of nonopiate leu-enkephalin analog prevents the development of posthypoxic alterations in newborn rats. The administration of hydra peptide morphogen inhibits the proliferation of tracheal epithelium and lowers the activity of the antioxidant defense of the lungs in newborn rats.
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References
V. B. Gavrilov and N. I. Mishkorudnaya,Lab. Delo, No 3, 33–36 (1983).
G. M. Kalivetskaya, S. S. Timoshin, A. L. Lykov,et al., Byull. Eksp. Biol. Med.,93, No 4, 48–53 (1982).
V. Z. Lankin and S. M. Gurevich,Dokl. Akad. Nauk SSSR,226, No 3, 705–708 (1976).
F. Z. Meerson,Pat. Fiziol., No 3, 7–15 (1973).
V. K. Rybal'chenko, in:Problems of Hypothalamus Physiology [in Russian], Kiev (1987), No 21, pp. 76–79.
V. K. Rybal'chenko, T. V. Ostrovskaya, and N. E. Kucherenko,Byull. Eksp. Biol. Med.,108, No 12, 681–683 (1989).
L. I. Utkina and S. S. Timoshin,,112, No 9, 296–298 (1991).
T. N. Fedorova, T. S. Korshunova, and S. G. Larskii,Lab. Delo, No 3, 25–27 (1983).
A. Yu. Khomichuk and S. S. Timoshin,Byull. Eksp. Biol. Med.,112, No 9, 307–308 (1991).
R. F. Beers and I. W. Sizer,J. Biol. Chem.,195, 133–140 (1952).
L. D. Hansen and W. T. Wariorick,Amer. J. Clin. Pathol.,46, 117 (1966).
T. Hianik and G. Laputkova,Gen. Physiol. Biophys.,10, No 1, 19–30 (1991).
L. W. Oberley and D. R. Spits,Handbook for Oxy Radical Research, CRC Press (1985).
D. F. Sargent, J. W. Bean, and R. Schwyser,Biophys. Chem.,34, No 1, 103–114 (1989).
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, No 5, pp. 535–537, May, 1994
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Lebed'ko, O.A., Timoshin, S.S. The use of a nonopiate leu-enkephalin analog and of hydra peptide morphogen for the correction of proliferation disturbances in tracheal epithelium and of LPO processes in lungs of newborn rats exposed to prenatal hypoxia. Bull Exp Biol Med 117, 536–538 (1994). https://doi.org/10.1007/BF02444311
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DOI: https://doi.org/10.1007/BF02444311