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Hepatoprotective Effect of Neonatal Administration of Non-Opioid Leu-Enkephalin Analogue in Adult Albino Rats Subjected to Antenatal Hypoxia

  • GENERAL PATHOLOGY AND PATHOPHYSIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effects of neonatal administration of non-opioid leu-enkephalin analogue peptide NALE) on the morphological parameters of the liver and redox status of 60-dayold albino rats subjected to antenatal hypoxia. In animals subjected to antenatal hypoxia, a decrease body weight and reduction of the area of hepatocytes and total area of their nucleoli were observed; these changes were accompanied by activation of free-radical processes and impairment of antioxidant defense in the liver and blood serum. Intraperitoneal administration of NALE (100 μg/kg, daily) during postnatal days 2-6 normalized body weight, hepatocyte area, and total area of their nucleoli, significantly reduced the intensity of ROS generation, and improved antioxidant protection in the liver and blood serum in 60-day-old animals subjected to antenatal hypoxia.

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Authors and Affiliations

  1. Far-Eastern State Medical University, Ministry of Health of the Russian Federation, Khabarovsk, Russia

    O. G. Pinaeva, O. A. Lebed’ko & E. N. Sazonova

  2. Khabarovsk Affiliated Branch of Far-Eastern Research Center of Respiratory Physiology and Pathology — Research Institute of Mother and Child Care, Khabarovsk, Russia

    O. A. Lebed’ko & E. N. Sazonova

  3. Computing Center of Far-Eastern Branch of the Russian Academy of Sciences, Khabarovsk, Russia

    S. K. Pinaev

Authors
  1. O. G. Pinaeva
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  2. O. A. Lebed’ko
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  3. S. K. Pinaev
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  4. E. N. Sazonova
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Corresponding author

Correspondence to O. G. Pinaeva.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 4, pp. 409-412, April, 2019

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Pinaeva, O.G., Lebed’ko, O.A., Pinaev, S.K. et al. Hepatoprotective Effect of Neonatal Administration of Non-Opioid Leu-Enkephalin Analogue in Adult Albino Rats Subjected to Antenatal Hypoxia. Bull Exp Biol Med 167, 428–431 (2019). https://doi.org/10.1007/s10517-019-04542-9

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  • DOI: https://doi.org/10.1007/s10517-019-04542-9

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