Skip to main content
SpringerLink
Log in

Changes of the level of cytochrome P-450 and NADPH-cytochrome P-450 reductase in rats with hereditary degeneration of the retina

  • Biophysics and Biochemistry
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In animals with hereditary degeneration of the retina the level of cytochrome P-450 in the brain microsomal fraction is found to be higher than that in healthy animals. In rats with hereditary degeneration of the retina the activity of NADPH-cytochrome P-450 reductase is unchanged in all tissues examined except for the retina, where it is markedly higher than in healthy animals on postnatal day 90.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M. L. Belen'kii,Elements of Quantitation of the Pharmacological Effect [in Russian], Riga (1959).

  2. G. V. Derviz,Lab. Delo, No 2, 67–72 (1973).

    PubMed  CAS  Google Scholar 

  3. M. G. Efimova,Ukr. Biokhim. Zh., No 2, 66–71 (1992).

    Google Scholar 

  4. I. I. Karuzina, G. I. Bachmanova, D. E. Mengazetdinov,et al., Biokhimiya, No 5, 1049–1057 (1979).

    Google Scholar 

  5. G. V. Lopashov and O. G. Stroeva,Development of the Eye in the Light of Experimental Studies [in Russian], Moscow (1963).

  6. V. M. Mishin and V. V. Lyakhovich,Multiple Forms of Cytochrome P-450 [in Russian], Novosibirsk (1985).

  7. V. E. Predtechenskii, V. M. Borovskaya, and L. T. Margolina,Laboratory Methods of Investigations [in Russian], Moscow (1950).

  8. D. H. Hubel,Eye, Brain, and Vision, Scientific American Library, A Division of HPHPL, New York (1988).

    Google Scholar 

  9. O. H. Lowry, H. J. Rosenbrough, A. L. Farr, and R. J. Randall,J. Biol. Chem.,193, 265–275 (1951).

    PubMed  CAS  Google Scholar 

  10. H. Nabeshima,Biochem. Pharmacol.,30, 1142–1144 (1984).

    Article  Google Scholar 

  11. T. Omura and R. Sato,J. Biol. Chem.,239, 2379–2385 (1964).

    PubMed  CAS  Google Scholar 

  12. H. Shichi,Exp. Eye Res.,8, 60–68 (1969).

    PubMed  CAS  Google Scholar 

  13. H. W. Strobel and J. D. Dignam,Meth. Enzymol.,52, 89–96 (1978).

    Article  PubMed  CAS  Google Scholar 

  14. R. Vijayalakshmi, K. A. Hindupur, and S. K. Shankar,Biochem. Pharmacol.,39, 1013–1018 (1990).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of the Molecular Basis of Sensory Perception; I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg (Presented by A. N. Klimov, Member of the Russian Academy of Medical Sciences)

    N. D. Shushakova & M. G. Efimova

Authors
  1. N. D. Shushakova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. G. Efimova
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, No 3, pp. 259–261, March, 1994

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shushakova, N.D., Efimova, M.G. Changes of the level of cytochrome P-450 and NADPH-cytochrome P-450 reductase in rats with hereditary degeneration of the retina. Bull Exp Biol Med 117, 261–264 (1994). https://doi.org/10.1007/BF02444157

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02444157

Key Words

Search

Navigation