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Time course of serotonin in platelets from patients with affective disorders

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Temporal variations in platelet levels of serotonin were found to be significantly decreased in patients with endogenous affective disorders, particularly those with the bipolar type of manic-depressive psychosis. The time course of serotonin content in these cells was not affected by either the sex or the age of the patients.In vitro incubation with lithium oxybutyrate raised mean platelet serotonin levels and stabilized their fluctuation in platelets from healthy subjects but not in those from the mental patients.

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Authors and Affiliations

  1. Institute of Mental Health, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk

    S. I. Karas', N. A. Kornetov, E. V. Makarova & O. L. Sherina

Authors
  1. S. I. Karas'
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  2. N. A. Kornetov
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  3. E. V. Makarova
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  4. O. L. Sherina
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, No 3, pp. 240–242, March, 1994

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Karas', S.I., Kornetov, N.A., Makarova, E.V. et al. Time course of serotonin in platelets from patients with affective disorders. Bull Exp Biol Med 117, 240–242 (1994). https://doi.org/10.1007/BF02444150

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  • DOI: https://doi.org/10.1007/BF02444150

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