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Effects of the membrane stabilizer ajmaline and the local anesthetic trimecaine on the pharmacological effects of strophanthinin vivo andin vitro

  • Pharmacology
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Abstract

Under conditions of simulated circulation failure in rats ajmaline increases tolerance for strophanthin cardiotoxicity to a greater extent than trimecaine. In isolated preparations of frog myocardium both antiarrhythmic agents somewhat weaken the inotropic effect of the cardiac glycoside and virtually do not influence its chronotropic effect.

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Authors and Affiliations

  1. Pharmacology, Department, Kuban Medical Institute, Krasnodar

    P. A. Galenko-Yaroshevskii, S. M. Lemkina & Ya. V. Kostin

Authors
  1. P. A. Galenko-Yaroshevskii
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  2. S. M. Lemkina
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  3. Ya. V. Kostin
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, No 1, pp. 59–61, January, 1994.

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Galenko-Yaroshevskii, P.A., Lemkina, S.M. & Kostin, Y.V. Effects of the membrane stabilizer ajmaline and the local anesthetic trimecaine on the pharmacological effects of strophanthinin vivo andin vitro . Bull Exp Biol Med 117, 61–64 (1994). https://doi.org/10.1007/BF02444082

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  • DOI: https://doi.org/10.1007/BF02444082

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