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Comparative Study of the Antiarrhythmic Activity of Liposomal Forms of Lappaconitine Hydrobromide and its Complex with Glycyrrhizic Acid Monoammonium Salt in the Aconitine Arrhythmia Model

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Results of a comparative study of the antiarrhythmic activity of liposomal forms of lappaconitine hydrobromide (LH) and its complex with the monoammonium salt of glycyrrhizic acid (MASGA) in the aconitine arrhythmia model (pathognomonic for class I antiarrhythmic drugs according to the VaughnWilliams classification) and the antiarrhythmic drug Allapinin® (lappaconitine hydrobromide) are presented. The liposomal form of LH/MASGA with a LH concentration of 1 ìg/mL is shown to restore effectively the contractile activity of papillary muscle. Moreover, the restored contractile activity persists for a longer time without arrhythmia recurrence than is observed for Allapinin, where arrhythmia recurred after 90 min. It is assumed that the liposomal form of LH/MASGA may become a promising antiarrhythmic drug because of a marked decrease in the toxic effect and a pronounced trend toward a decrease in the time required to restore heart rhythm without arrhythmia recurrence.

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References

  1. A. L. Syrkin and A. V. Dobrovol’skii, Consilium Medicum, 10, 492 – 496 (2001).

    Google Scholar 

  2. A. N. Okorokov, Diagnosis of Internal Organ Diseases [in Russian], Vol. 7, Moscow (2006).

  3. J. Constant, Bedside Cardiology, Lippincott Williams & Wilkins, Philadelphia (1999) [Russian translation, Moscow (2004)].

  4. P. Kh. Dzhanashiya, N. M. Shevchenko, et al., Serdtse: Zh. Prakt. Vrachei, 2(2), 97 – 99 (2002).

    Google Scholar 

  5. Yu. N. Belenkov and V. Yu. Mareev, Serdechno-Sosud. Nedostatochn., 1(3), 7 – 11 (2002).

    Google Scholar 

  6. B. Ya. Bart, O. L. Smirnova, V. G. Larin, and L. A. Morozovskaya, Kardiologiya, 3(37), 33 – 36 (1997).

    Google Scholar 

  7. V. D. Vakhlyaev, A. V. Nedostup, D. A. Tsaregorodtsev, and M. Yu. Mazing, Ross. Med. Zh., 2, 54 – 56 (2000).

    Google Scholar 

  8. G. M. Solov’yan and T. V. Mikhaleva, Ukr. Kardiol. Zh., 2(26), 76 – 90 (2019).

    Google Scholar 

  9. E. I. Chazov, Serdtse: Zh. Prakt. Vrachei, 1(1), 6 – 8 (2002).

    Google Scholar 

  10. M. Akhtar, H. Garan, M. H. Lehmann, et al., Ann. Intern. Med., 114(6), 499 – 512 (1991).

    Article  CAS  Google Scholar 

  11. B. M. Altura, Magnesium Trace Elem., 167 – 171 (1991).

  12. S. F. Sokolov, Vestn. Aritmol., 64, 60 – 70 (2011).

    Google Scholar 

  13. A. A. Kotlyarov, O. A. Dmitrieva, L. M. Mosina, and T. N. Karyakina, Klin. Med., No. 9, 57 – 59 (2012).

  14. S. G. Kanorskii, Kardiologiya, 54(2), 60 – 65 (2014).

    Google Scholar 

  15. Yu. N. Zamotaev, Yu. A. Kremnev, N. A. Grinenko, and S. E. Podshibyakin, Russ. Med. Zh., No. 9, 518 (2003).

  16. V. V. Plechev, Sh. Z. Zagidullin, V. M. Yunusov, et al., Kardiologiya, 53(8), 34 – 39 (2013).

    CAS  Google Scholar 

  17. D. P. Zipes, A. J. Camm, M. Borggrefe, et al., Circulation, 114, e385-e484 (2006).

    Article  Google Scholar 

  18. S. F. Sokolov, M. M. Belyaeva, et al., Kardiologiya, 57(4), 45 – 52 (2017).

    CAS  Google Scholar 

  19. F. N. Dzhakhangirov and S. F. Sokolov, New Antiarrhythmic Medicine Allapinin (Pharmacology and Clinical Use), Tashkent (2004).

  20. Zh. F. Ziyavitdinov, U. Zh. Ishimov, N. Sh. Berdiev, et al., Khim.-farm. Zh., 56(2), 25 – 32 (2022); Pharm. Chem. J., 56(2), 167 – 173 (2022).

  21. V. V. Uzbekov, B. F. Abdullaev, Yu. I. Oshchepkova, and Sh. I. Salikhov, Vestn. Farm., 3(85), 94 – 101 (2019).

    Google Scholar 

  22. European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes; http://www.lawmix.ru/abro.php?id=11036.

  23. N. V. Kaverina, Kardiologiya, 26(8), 59 – 63 (1986).

    Google Scholar 

  24. M. M. Musaev, P. B. Usmanov, et al., Computer program “Analysis of the kinetics of muscle contraction”: State Patent Office of the RUz. Certificate No. DGU 01873. Dec. 18, 2009 / Official Bulletin, 1(9), 170 – 171.

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Authors and Affiliations

  1. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, 83 Mirzo Ulugbek St., Tashkent, Uzbekistan, 100125

    V. V. Uzbekov, B. F. Abdullaev, Yu. I. Oshchepkova & Sh. I. Salikhov

  2. Institute of Biophysics and Biochemistry, National University of Uzbekistan, 174 Talabalar St., Tashkent, Uzbekistan, 100095

    I. Z. Jumayev & P. B. Usmanov

Authors
  1. V. V. Uzbekov
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  2. B. F. Abdullaev
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  3. I. Z. Jumayev
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  4. Yu. I. Oshchepkova
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  5. P. B. Usmanov
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  6. Sh. I. Salikhov
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Correspondence to Yu. I. Oshchepkova.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 56, No. 10, pp. 23 – 29, October, 2022.

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Uzbekov, V.V., Abdullaev, B.F., Jumayev, I.Z. et al. Comparative Study of the Antiarrhythmic Activity of Liposomal Forms of Lappaconitine Hydrobromide and its Complex with Glycyrrhizic Acid Monoammonium Salt in the Aconitine Arrhythmia Model. Pharm Chem J 56, 1327–1332 (2023). https://doi.org/10.1007/s11094-023-02793-5

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  • DOI: https://doi.org/10.1007/s11094-023-02793-5

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