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Experimental models of Reye's syndrome

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Abstract

Intraperitoneal administration of 4-pentenoic acid (20 mg/kg/day for seven days or ten doses of 50 mg/kg with 4 h intervals) or acetylsalicylic acid (50 mg/kg 1 hour after single pyrogenal injection) to rats reproduced metabolic disorders characteristic of Reye's syndrome: hyperenzymemia, hyperbilirubinemia, decreased levels of ketone bodies and urea, hypoglycemia, hypoproteinemia, accumulation of ammonia and phenol, and acidosis. Necroses and microvesicula steatosis were found in the liver.

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Authors and Affiliations

  1. Department of Pharmacology, Medico-Biological Faculty, Siberian Medical University, Tomsk

    A. S. Saratikov, A. I. Vengerovskii, A. G. Arbuzov, V. S. Chuchalin, M. B. Chervyakova & I. V. Sukhodolo

  2. Department of Anatomy and General Pathology, Medico-Biological Faculty, Siberian Medical University, Tomsk

    A. S. Saratikov, A. I. Vengerovskii, A. G. Arbuzov, V. S. Chuchalin, M. B. Chervyakova & I. V. Sukhodolo

Authors
  1. A. S. Saratikov
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  2. A. I. Vengerovskii
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  3. A. G. Arbuzov
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  4. V. S. Chuchalin
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  5. M. B. Chervyakova
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  6. I. V. Sukhodolo
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 4, pp. 475–477, April, 2000

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Saratikov, A.S., Vengerovskii, A.I., Arbuzov, A.G. et al. Experimental models of Reye's syndrome. Bull Exp Biol Med 129, 400–402 (2000). https://doi.org/10.1007/BF02439283

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  • DOI: https://doi.org/10.1007/BF02439283

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