Abstract
In experiments on anesthetized cats, aconitine produced direct arrhythmogenic and cardiotoxic effects on the myocardium combined with indirect cardiotropic effects mediated via activation of extracardial nerves. Aconitine demonstrated pronounced cholinolytic properties and blocked vagal arrhythmogenic effect.
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References
G. E. Batrak and A. N. Kudrin,Dosage of Drugs for Experimental Animals [in Russian], Moscow (1979).
S. Yu. Berdyaev,The Search for and Pharmacological Study of the Agents Improving Electrical Stability of the Myocardium, Abstract of Doct. Med. Sci. Dissertation, Moscow (1992).
V. V. Gatsura and A. S. Saratikov,Pharmacological Agents in Experimental Medicine and Biology [in Russian], Tomsk (1977).
N. V. Kaverina, S. Yu. Berdyaev, E. P. Kishchuk, and O. E. Paskhina,Vedom. Farmakol. Komit., No. 2, 11–19 (1998).
P. G. Kostyuk, D. M. Grodzinskii, V. L. Zima,et al., Biophysics [in Russian], Kiev (1988).
B. N. Pavlov,Proceedings of II Moscow State Medical Institute, Ser. Fiziol.,40, No. 1, 140–146 (1976).
Yu. P. Sheikh-Zade and V. V. Vovereidt,Fiziol. Zh. SSSR,68, No. 6, 824–825 (1982).
Yu. P. Sheikh-Zade and P. A. Galenko-Yaroshevskii,Byull. Eksp. Biol. Med.,104, No. 9, 261–263 (1987).
Yu. P. Sheikh-Zade, A. V. Kubantsev, and P. A. Galenko-Yaroshevskii,Byull. Izobret., No. 46, (1989).
L. SzekeresProgr. Pharmacol.,2, No. 4, 25–31 (1979).
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 4, pp. 434–436, April, 2000
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Sheikh-Zade, Y.R., Cherednik, I.L. & Galenko-Yaroshevskii, P.A. Peculiarities of cardiotropic effect of aconitine. Bull Exp Biol Med 129, 365–366 (2000). https://doi.org/10.1007/BF02439272
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DOI: https://doi.org/10.1007/BF02439272