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Pharmacokinetics of new nootropic acylprolyldipeptide and its penetration across the blood-brain barrier after oral administration

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Pharmacokinetics of GVS-111, a new acylprolyldipeptide with nootropic properties and its penetration across the blood-brain barrier were studied in rats using HPLC. It was found that the dipeptide is absorbed in the gastrointestinal tract, enters the circulation, and penetrates through the blood-brain barrier in an umodified state.

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Authors and Affiliations

  1. Laboratory of Pharmacokinetics, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    S. S. Boiko, R. U. Ostrovskaya, V. P. Zherdev, S. A. Korotkov, T. A. Gudasheva, T. A. Voronina & S. B. Seredenin

Authors
  1. S. S. Boiko
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  2. R. U. Ostrovskaya
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  3. V. P. Zherdev
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  4. S. A. Korotkov
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  5. T. A. Gudasheva
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  6. T. A. Voronina
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  7. S. B. Seredenin
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 4, pp. 426–429, April, 2000

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Boiko, S.S., Ostrovskaya, R.U., Zherdev, V.P. et al. Pharmacokinetics of new nootropic acylprolyldipeptide and its penetration across the blood-brain barrier after oral administration. Bull Exp Biol Med 129, 359–361 (2000). https://doi.org/10.1007/BF02439270

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  • DOI: https://doi.org/10.1007/BF02439270

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