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Histopathology and ultrastructure of the liver under combined action of narcotics and hepatitis C and B viruses

  • Morphology and Pathomorphology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Liver autopsy material from opioid addicts with viral hepatitis C and C+B showed hepatocyte dystrophy associated with lipid infiltration, hyperplasia of lymphoid tissue, and perivascular fibrosis. Alteration of hepatocytes were most pronounced in patients with hepatitis C+B. Ultrastructure of hepatocytes is characterized by a reduction of protein synthesizing compartment, an increase in volume density of smooth cytoplasmic reticulum, appearance of megamitochondria, and pronounced collagenization of the Disse space.

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Authors and Affiliations

  1. Laboratory of Ultrastructural Bases of Pathology, Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    G. I. Nepomnyashchikh, N. P. Tolokonskaya, E. G. Sakharova, S. V. Aidagulova, G. A. Mezentseva & L. M. Nepomnyashchikh

Authors
  1. G. I. Nepomnyashchikh
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  2. N. P. Tolokonskaya
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  3. E. G. Sakharova
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  4. S. V. Aidagulova
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  5. G. A. Mezentseva
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  6. L. M. Nepomnyashchikh
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 9, pp. 351–355, September, 1999

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Nepomnyashchikh, G.I., Tolokonskaya, N.P., Sakharova, E.G. et al. Histopathology and ultrastructure of the liver under combined action of narcotics and hepatitis C and B viruses. Bull Exp Biol Med 128, 963–966 (1999). https://doi.org/10.1007/BF02438098

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  • DOI: https://doi.org/10.1007/BF02438098

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